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The association between PCSK9 inhibitor use and sepsis – A systematic review and meta-analysis of 20 double-blind, randomized, placebo-controlled trials
Chatgpt in scientific writing: a cautionary tale.
Gender equality in national cardiology societies: a cross-sectional study
Report from the retreat on meaningful use.
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Using Online Colorectal Cancer Risk Calculators to Guide Screening Decision-Making
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The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine , both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine , a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.
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Research articles
Optimal dietary patterns for prevention of chronic disease
Analyses of eight dietary patterns revealed that adherence to low insulinemic, low inflammatory or diabetes risk-reducing diets was associated with the largest risk reduction of cardiometabolic diseases and cancer in US men and women.
- Mingyang Song
- Edward L. Giovannucci
A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy
Conserved microbiome features across clinical and geographical variations may enable microbiome-based predictions of outcomes in CD19-targeted CAR-T cell immunotherapy
- Christoph K. Stein-Thoeringer
- Neeraj Y. Saini
- Eran Elinav
Comparison of two diagnostic intervention packages for community-based active case finding for tuberculosis: an open-label randomized controlled trial
Better approaches are crucial to improve identification of people with active tuberculosis (TB), accelerate treatment and curtail disease transmission. A randomized trial suggests that a mobile clinic using DNA-based diagnosis is one such tool to reduce time to treatment of individuals with TB.
- Aliasgar Esmail
- Philippa Randall
- Keertan Dheda
Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections
Dysbiosis of the gut microbiome in critically ill patients, coupled with impaired innate immune responses, may lower the barrier to acquiring infectious pathogens in the hospital setting.
- Jared Schlechte
- Amanda Z. Zucoloto
- Braedon McDonald
Evolution of synchronous female bilateral breast cancers and response to treatment
Clinical, genomic and transcriptomic analyses of paired samples of synchronous bilateral female breast cancer identify associations between tumor concordance and immune infiltrates levels and response to neoadjuvant treatment.
- Anne-Sophie Hamy
- Judith Abécassis
- Fabien Reyal
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts
In a cohort of patients with cerebral arachnoid cysts, multiomic analyses reveal de novo variants causing genetic neurodevelopmental conditions in up to 16% of cases, suggesting that surgery in these cases may not improve non-mass effect-related symptoms.
- Adam J. Kundishora
- Garrett Allington
- Kristopher T. Kahle
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial
The potential of evinacumab, a monoclonal antibody targeting angiopoietin-like 3, for reducing triglyceride levels was tested in patients with severe hypertriglyceridemia due to differing genetic etiologies.
- Robert S. Rosenson
- Daniel Gaudet
- Daniel J. Rader
Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer
A combination of real-world evidence and a reanalysis of phase 3 clinical trial data unveils KRAS codon G12 mutations as a biomarker of resistance to trifluridine/tipiracil in metastatic colorectal cancer.
- Joris van de Haar
- Nicola Valeri
A deep-learning algorithm to classify skin lesions from mpox virus infection
A deep-learning algorithm was developed to identify skin lesions caused by the mpox virus and was then implemented in a web-based app designed for patient use.
- Alexander H. Thieme
- Yuanning Zheng
- Olivier Gevaert
Predicting the efficacy of variant-modified COVID-19 vaccine boosters
Neutralizing antibody titers elicited by either ancestral or bivalent COVID-19 vaccine boosters are predicted to increase protection against severe disease due to SARS-CoV-2 variants.
- David S. Khoury
- Steffen S. Docken
- Deborah Cromer
The artificial sweetener erythritol and cardiovascular event risk
Metabolomics analyses reported an increased risk of cardiovascular disease associated with the artificial sweetener erythritol, supported by mechanistic studies showing that high levels of erythritol enhanced platelet reactivity and thrombosis formation.
- Marco Witkowski
- Stanley L. Hazen
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
A novel multi-omics workflow, combining gut microbiome metagenomics, metatranscriptomics and metabolomics, enabled the identification of the microbial pathways responsible for the degradation of the immunomodulatory drug 5-ASA in the gut of patients with inflammatory bowel disease.
- Raaj S. Mehta
- Jared R. Mayers
- Curtis Huttenhower
Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial
The dual IDH1/IDH2 inhibitor vorasidenib exhibited better brain permeability and target engagement than ivosidenib in a pilot perioperative randomized clinical trial in patients with IDH1-mutant glioma.
- Ingo K. Mellinghoff
- Timothy F. Cloughesy
Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis
Electrical stimulation of cervical spinal circuits facilitates arm and hand movements in two participants with moderate and severe chronic post-stroke hemiparesis.
- Marc P. Powell
- Nikhil Verma
- Marco Capogrosso
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation
The recipient of an allogeneic stem cell transplant from a CCR5Δ32/Δ32 donor shows evidence of HIV type 1 cure, including the absence of a viral rebound over 4 years after stopping antiretroviral treatment.
- Björn-Erik Ole Jensen
- Elena Knops
- Guido Kobbe
Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice
Adenine base editing successfully corrected a MYH7 pathogenic variant that causes hypertrophic cardiomyopathy in human cardiomyocytes and a mouse model of the disease, highlighting the potential of the approach to correct monogenic variants causing cardiac disease.
- Andreas C. Chai
- Eric N. Olson
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice
Two approaches using an adenine base editor and a Cas9 nuclease prevented the development of hypertrophic cardiomyopathy in mice carrying a pathogenic mutation on the Myh6 gene, highlighting the potential of single-dose genetic therapies for the treatment of cardiac disease.
- Daniel Reichart
- Gregory A. Newby
- Christine Seidman
Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial
The FLIGHT-FXR trial, testing farnesoid X receptor agonist tropifexor in nonalcoholic steatohepatitis, demonstrated sustained decreases in alanine aminotransferase levels and hepatic fat fraction, but not aspartate aminotransferase, with dose-dependent pruritus being the most common adverse event.
- Arun J. Sanyal
- Patricia Lopez
- Clifford A. Brass
Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial
Intratumoral injection of the oncolytic virus talimogene laherparepvec (T-VEC) during weekly paclitaxel before neoadjuvant doxorubicin and cyclophosphamide led to clinical benefit and was well tolerated in patients with stage 2–3 triple-negative breast cancer.
- Hatem Soliman
- Deanna Hogue
- Brian Czerniecki
Prevalence of smoldering multiple myeloma based on nationwide screening
A nationwide screening program from the iStopMM study performed in Iceland to detect smoldering multiple myeloma reported a prevalence of 0.5% in individuals over 40 years of age, with increasing risks with age and in males.
- Sigrún Thorsteinsdóttir
- Gauti K. Gíslason
- Sigurður Y. Kristinsson
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Serum Fibroblast Growth Factor 23 and FGF23 Gene Variants in Patients with Type 2 Diabetes and Essential Hypertension. Association with Chronic Kidney Disease
Protein-based nanoparticle vaccine approaches against infectious diseases, impact of nutritional management on survival of critically ill malnourished patients with refeeding hypophosphatemia, differential expression of fxr and genes involved in inflammation and lipid metabolism indicate adipose tissue dysfunction in gestational diabetes, impaired extracellular proteostasis in patients with heart failure, potential role of vitamin d, ace2 and the proteases as tmprss2 and furin on sars-cov-2 pathogenesis and covid-19 severity, cumulative muscle strength and risk of cardiovascular disease and all-cause mortality: a prospective cohort study, uropathogenic escherichia coli in mexico, an overview of virulence and resistance determinants: systematic review and meta-analysis, erratum to “multiple sclerosis-associated bacterial ligand 654” [archives of medical research 53/2(february 2022) 157-162/arcmed_2021_2713], note to users :.
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