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What is a clinical trial?
A clinical trial is the process by which new medications, vaccines, medical devices and procedures are studied and tested to determine whether they are safe and effective for treating or preventing diseases and health conditions. By joining a clinical trial, you help to advance new and potentially lifesaving treatments for patients who need them.
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Browse paid clinical trial opportunities at one of our three U.S. locations in Dallas, Texas; Madison, Wisconsin; or Daytona Beach, Florida.
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Once you pass the phone screen you will be scheduled for a screening appointment at the clinic. It is important to follow any fasting requirements before this appointment. Bring a current, valid, government ID with you and be on time. Not showing up for an appointment could hurt your chances of getting in a study later on. Please allow 2–4 hours for this appointment.
What to expect during your stay
Most of the time participants check into the clinic the day before the study begins. This is to help you get settled and comfortable. We will assign you to a room, give you a wrist band, and go over the rules of the clinic and anything particular to your study. The clinics are very much like a hospital floor. You will share a room with at least four other people of the same sex. You will have a secure place to store your belongings. We want you to be comfortable and at ease while you are at the clinic. When you are not having procedures done, you can read, watch TV, play games, join in activities like pool and Bingo, or use your laptop or phone if you’ve brought one. Each clinic has laundry facilities as well if you will be staying with us for a while.
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Answering your frequently asked questions about paid medical trials
What are the risks and benefits of taking part in a clinical trial.
Before a drug can be prescribed, it must go through a long testing and approval process, including clinical studies. A clinical study is used to test new drugs (medications) and develop new uses for existing drugs. At our research clinics, we work with some of the world’s leading companies on studies to answer questions like:
- How is a drug absorbed into the body?
- How does one drug react to another drug?
- How is a drug affected by food?
Are the rumors about clinical trials true?
There are plenty of misconceptions about what happens on a clinical research study. These are just that: myths. Your safety is our number one priority. Drug development is highly regulated with strict safety and ethical guidelines and we take those regulations very seriously.
Will I be paid for taking part in a research study?
You will be paid for your time and participation in the study. Compensation is based on the length of the study, the number of overnight stays in our clinic, and the number of outpatient visits you attend.
Browse a list of our current studies and the payment details for each. Call us at 866-429-3700 to see if you're eligible.
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When you join a paid research study, you contribute to advances in new medicines that can ultimately transform patients’ lives.
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Advancing Medicine Through Clinical Trials
Your opportunity to participate.
As a patient, you may be eligible to participate in clinical research. Your doctor can help determine whether a clinical trial is right for you.
Medical research discovers ways to help people live longer, improve their quality of life and manage or cure disease. Improvements to care are possible because of the people who volunteer to participate in clinical research.
Research studies called clinical trials test how new medications or treatments work. Patients who participate have access to these new drugs and treatments. Clinical trials can also help physicians learn how to improve care for future patients.
Our clinical trials
Cancer clinical trials.
Nearly all cancer treatments used today were studied and made available to patients through clinical trials. In the last 6 years alone, our researchers have advanced 7 new cancer drugs into clinical trials.
Heart care clinical trials
As a heart patient, you may have the opportunity to participate in clinical trials. These studies help develop new medications and procedures that may make a difference in your own care and the care of others.
Urology clinical trials
Through a combination of basic science research and clinical studies, our urology team engages in research that may make a difference in the lives of our patients today and tomorrow.
National Library of Medicine
View all of the clinical trials now open at The University of Kansas Health System.
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Frequently asked questions, types and phases.
For more information on clinical trials, call 913-588-1227 or toll-free 844-323-1227.
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Missouri Clinical Trials
Below are actively recruiting clinical trials for Missouri. Click on the closest city to find the research studies that are available in your area.
- Additional Locations 197 total 4 new 40 updated
- Ballwin 274 total 4 new 58 updated
- Belton 84 total 4 new 11 updated
- Bolivar 99 total 4 new 18 updated
- Bonne Terre 46 total 4 new 3 updated
- Branson 53 total 4 new 5 updated
- Bridgeton 281 total 4 new 58 updated
- Cape Girardeau 159 total 4 new 42 updated
- Chesterfield 289 total 4 new 61 updated
- Columbia 202 total 4 new 17 updated
- Creve Coeur 1,218 total 4 new 172 updated
- Farmington 67 total 4 new 7 updated
- Florissant 183 total 4 new 33 updated
- Gladstone 301 total 4 new 53 updated
- Hazelwood 282 total 4 new 58 updated
- Independence 379 total 4 new 66 updated
- Jackson 159 total 4 new 42 updated
- Jefferson City 112 total 4 new 23 updated
- Joplin 115 total 4 new 24 updated
- Kansas City 806 total 4 new 140 updated
- Lee's Summit 107 total 4 new 22 updated
- Liberty 54 total 4 new 3 updated
- Mexico 44 total 4 new 2 updated
- O'Fallon 147 total 4 new 32 updated
- Ozark 74 total 4 new 8 updated
- Rolla 111 total 4 new 22 updated
- Saint Louis 1,162 total 4 new 164 updated
- Sainte Genevieve 49 total 4 new 3 updated
- Springfield 126 total 4 new 24 updated
- St. Ann 350 total 4 new 64 updated
- St. Charles 287 total 4 new 59 updated
- St. Joseph 136 total 4 new 22 updated
- St. Louis 1,162 total 4 new 164 updated
- St. Peters 178 total 4 new 39 updated
- Sullivan 70 total 4 new 7 updated
- Sunset Hills 975 total 4 new 134 updated
- Warrensburg 46 total 4 new 3 updated
- Washington 62 total 4 new 6 updated
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What Are Clinical Trials
cience is only as good as the evidence it is based upon. Since medical science has such a vital effect on our health it is important that every decision is based on strong clinical evidence. This evidence that is provided by clinical trials and research. The National Institutes of Health (NIH) describe clinical trials as “research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans” (1). Clinical trials often look for both healthy participants and individuals with specific conditions. Paid clinical trials are sometimes available for individuals looking to be compensated for their time.
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- Access to cutting-edge treatments
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Importance of Clinical Trials
Clinical trials provide us with details about the effectiveness and safety of a clinical intervention. Many clinical trials help researchers come up with better treatment strategies for a certain disease, thus, some clinical trials compare the two treatment methods to find out which one is better and safer.
Clinical trials don’t study just the newest medications or interventions; they may be used to study the long-term effects of drugs and interventions that are already in common use. For example, recent clinical trials have found that hormonal therapy –which is already widely used- increases the risk of heart disease, stroke, blood clots and breast cancer. As a result, long-term use of hormonal therapy is no longer recommended in postmenopausal women (2).
Phases of Clinical Trials
Clinical trials are divided into phases. Each phase has different objectives and questions to answer. Scientists usually start a clinical trial on humans only after they have found a particular medication or intervention is effective in a laboratory or through animal studies. According to the FDA, clinical trials are carried out in four phases, with each phase building upon the knowledge gained from the prior phase (3). If the trial fails to fulfill its objective, it may be terminated (4).
Generally carried out in a very small group of people (usually 20-100 healthy subjects). The main objective of this trial is to understand safety, and safe dosages in humans.
In this phase, the trial is carried out on a larger group of people (several hundred people), and the objective is to know more about the effectiveness of medication or intervention, along with a collection of additional safety data.
Once the drug or intervention has been found safe and effective, it is tested on a much larger group of humans (usually few thousand) over the period of few years. If found effective and safe enough, it is given a marketing approval by FDA.
The final phase, involving several thousand individuals suffering from the condition for which intervention or medication is being tested. Tests focus on the efficacy and safety on a much larger scale and in real life conditions.
It is also important to understand that not all clinical trials involve the study of new medications or interventions. For example, the genetic study of a group that suffers from a certain disease, or effect of living conditions on cardiac health.
Why do People Participate in Clinical Trials?
Everyone has different reasons to participate in a clinical trial. Healthy subjects mostly participate because they think that it is their duty to help science in moving forward. Many people suffering from diseases may participate in the hopes of getting better or cured. There are many medical conditions for which there is currently no effective treatment, such as HIV, different kinds of cancers, Crohn’s disease , or even asthma .
There are certain eligibility criteria to decide who can participate in every clinical trial. Some trials require the participation of older people, while others focus on younger adults. Some may need healthy volunteers while others need patients with a particular disease condition. Trials may also vary in duration and location where they would be carried out. In some trials, a person may need to travel or stay at the medical facility.
What are the Benefits of Participation in a Clinical Trial?
Benefits depend upon the phase or type of clinical trial. Clinical trials provide a person early access to the latest developments in the field of medicine. A person also gets attention from the best specialists in their field, along with much better diagnostics. Apart from the possibility of direct health benefits, individuals get an opportunity to play a role in the development of science.
How Safe are Clinical Trials?
There is no guarantee that a person would benefit from any particular clinical trial. Some interventions or medications may cause unforeseen and severe side effects.
A person is informed about the possible risks when signing the informed consent. It is also important to know that informed consent is not a contract and a person can withdraw from the study at any given time.
What Should a Person Know About the Trial?
Although fully understanding clinical trials can be difficult if you don’t have a background in science or healthcare, the official website of the US government for clinical trials has come up with a list of questions that may help a person to know more about clinical studies. Below is the list of questions you should ask before giving consent to participate (5);
- Ask about the purpose of the clinical trial.
- Ask about the possible benefits and risks from the trial, and if the trial with that particular intervention has been done earlier or not.
- Ask about your options or compensation methods in case of injury.
- Ask about the long term care provided, after the clinical trial has ended.
- Ask about the financial benefits for participation and coverage of participation costs.
- Ask about the length of the proposed clinical trial.
- Ask if the study would require hospitalization or not.
- Ask about the possible benefits of the intervention being tested, as compared to the treatment that is already being used.
- Ask about the interventions involved in the trial, and what a person has to do for the participation, procedures involved, a number of hospital visits.
Available Clinical Research Trials
Condition: Postoperative Retention of UrineInterventions: Drug: Tamsulosin; Drug: PlaceboSponsor: NorthShore University HealthSystemNot yet recruiting
Conditions: Mental Health Symptoms; WearablesIntervention: Sponsors: 4YouandMe; Mind Medicine, Inc.; Vector Institute for Artificial Intelligence; Cambridge Cognition Ltd; University of WashingtonNot yet recruiting
Condition: Problem;Behaviour;ChildInterventions: Behavioral: Student Intervention Matching System (SIMS); Behavioral: group-based social skills trainingSponsors: University of Iowa; University of MinnesotaCompleted
Condition: Food SecurityIntervention: Sponsors: NYU Langone Health; National Institute on Aging (NIA)Not yet recruiting
Conditions: Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Metastatic Malignant Neoplasm in the PeritoneumInterventions: Procedure: Biospecimen Collection; Drug: Cisplatin; Procedure: Computed Tomography; Drug: Docetaxel; Procedure: Gastrectomy; Drug: Hyperthermic Intraperitoneal Chemotherapy; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Other: Questionnaire AdministrationSponsor: Mayo ClinicNot yet recruiting
Condition: Prostate CancerInterventions: Drug: Early TAP Block; Drug: Late TAP BlockSponsor: William Beaumont HospitalsEnrolling by invitation
Conditions: Autism Spectrum Disorder; Bone HealthInterventions: Drug: 1. Intranasal oxytocin spray; Drug: 2. Intranasal placebo spray; Drug: 3. Intranasal Oxytocin spraySponsors: Massachusetts General Hospital; United States Department of DefenseNot yet recruiting
Conditions: Health Behavior; Total Worker Health; Occupational HealthIntervention: Other: Total Worker Health for Wildland FirefightersSponsors: Oregon Health and Science University; Federal Emergency Management Agency; National Fallen Firefighters FoundationCompleted
Conditions: Anxiety Disorders and Symptoms; Depressive Symptoms; DepressionIntervention: Behavioral: MAYA Mobile ApplicationSponsor: Weill Medical College of Cornell UniversityNot yet recruiting
Conditions: Parkinson Disease; Dysarthria, HypokineticInterventions: Behavioral: Clear Speech; Behavioral: Less Clear SpeechSponsors: Florida State University; National Institute on Deafness and Other Communication Disorders (NIDCD)Recruiting
Conditions: Chronic Pain; Acute Pain; Post Operative Pain; Fibromyalgia, Primary; Fibromyalgia, Secondary; Fibromyalgia; Irritable Bowel Syndrome; Chronic Headache Disorder; Chronic Migraine; Chronic Pelvic Pain Syndrome; Temporomandibular Joint Disorders; Endometriosis-related Pain; Arthritis; Chronic Low-back Pain; Failed Back Surgery Syndrome; Post Herpetic Neuralgia; Neuropathic Pain; Painful Diabetic Neuropathy; Painful Bladder Syndrome; Trauma-related Wound; Trauma, Multiple; Chronic Pain Syndrome; Chronic Shoulder PainIntervention: Device: SOMA pain manager smartphone applicationSponsor: Brown UniversityNot yet recruiting
Conditions: Head and Neck Cancer; Obstructive Sleep ApneaIntervention: Device: Nerve stimulation using nerve stimulation device and sterile wire electrode.Sponsor: Vanderbilt University Medical CenterNot yet recruiting
Conditions: Colonoscopy; Positive-Pressure RespirationInterventions: Device: Nasal Cannula; Device: Nasal Positive Airway Pressure SystemSponsor: Indiana UniversityNot yet recruiting
Conditions: Parkinson Disease; Deep Brain StimulationInterventions: Device: Burst-type DBS electrical stimulation programming; Device: Standard of care DBS programmingSponsors: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Boston Scientific CorporationRecruiting
Conditions: Frailty; Cognitive Impairment; Dementia; Cognitive Impairment, Mild; Alzheimer Disease; Alzheimer Disease, Early OnsetIntervention: Sponsors: Baylor College of Medicine; BioSensics LLCRecruiting
Conditions: Anorexia Nervosa; Bulimia Nervosa; Anorexia Nervosa, Atypical; Bulimia; AtypicalIntervention: Behavioral: Mindful CourageSponsors: Yeshiva University; Yale UniversityRecruiting
Conditions: Bacterial Vaginosis; Vulvovaginal CandidiasisIntervention: Drug: PhexxiSponsors: Queen's Medical Center; University of Hawaii FoundationRecruiting
Conditions: Pediatric Neuromotor Diagnoses; Cerebral Palsy; Hypoxia, BrainIntervention: Behavioral: Aquatic therapySponsors: Ohio State University; Franklin County Board of Developmental DisabilitiesRecruiting
Conditions: Barretts Esophagus With Dysplasia; Barrett Esophagus; Esophageal AdenocarcinomaIntervention: Procedure: Endoscopic Eradication TherapySponsors: University of Colorado, Denver; Baylor University; University of North Carolina; Medical University of South CarolinaRecruiting
Conditions: Bone Infection; Joint Infection; Bone and Joint InfectionInterventions: Drug: Omadacycline Pill; Drug: Standard of CareSponsors: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; Paratek Pharmaceuticals IncNot yet recruiting
Match to Clinical Trials
- What Are Clinical Trials? – NHLBI, NIH. [cited 2017 Sep 10]. Available from: https://www.nhlbi.nih.gov/studies/clinicaltrials
- Why Are Clinical Trials Important? – NHLBI, NIH. [cited 2017 Sep 10]. Available from: https://www.nhlbi.nih.gov/studies/clinicaltrials/important
- What Are the Different Types of Clinical Research? [cited 2017 Sep 10]. Available from: https://www.fda.gov/forpatients/clinicaltrials/types/default.htm
- US FDA. The Drug Development Process – Step 3: Clinical Research. 2017 [cited 2017 Sep 10]. Available from: https://www.fda.gov/forpatients/approvals/drugs/ucm405622.htm
- Learn About Clinical Studies – ClinicalTrials.gov. [cited 2017 Sep 10]. Available from: https://clinicaltrials.gov/ct2/about-studies/learn
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Nih clinical research trials and you, finding a clinical trial, around the nation and worldwide.
NIH conducts clinical research trials for many diseases and conditions, including cancer , Alzheimer’s disease , allergy and infectious diseases , and neurological disorders . To search for other diseases and conditions, you can visit ClinicalTrials.gov.
ClinicalTrials.gov [ How to Use Search ] This is a searchable registry and results database of federally and privately supported clinical trials conducted in the United States and around the world. ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals.
Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read the disclaimer on ClinicalTrials.gov for details.
Before participating in a study, talk to your health care provider and learn about the risks and potential benefits.
At the NIH Clinical Center in Bethesda, Maryland
Search NIH Clinical Research Studies The NIH maintains an online database of clinical research studies taking place at its Clinical Center, which is located on the NIH campus in Bethesda, Maryland. Studies are conducted by most of the institutes and centers across the NIH. The Clinical Center hosts a wide range of studies from rare diseases to chronic health conditions, as well as studies for healthy volunteers. Visitors can search by diagnosis, sign, symptom or other key words.
Join a National Registry of Research Volunteers
ResearchMatch This is an NIH-funded initiative to connect 1) people who are trying to find research studies, and 2) researchers seeking people to participate in their studies. It is a free, secure registry to make it easier for the public to volunteer and to become involved in clinical research studies that contribute to improved health in the future.
This page last reviewed on November 6, 2018
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Research participants are partners in discovery at the NIH Clinical Center, the largest research hospital in America. Clinical research is medical research involving people The Clinical Center provides hope through pioneering clinical research to improve human health. We rapidly translate scientific observations and laboratory discoveries into new ways to diagnose, treat and prevent disease. More than 500,000 people from around the world have participated in clinical research since the hospital opened in 1953. We do not charge patients for participation and treatment in clinical studies at NIH. In certain emergency circumstances, you may qualify for help with travel and other expenses Read more , to see if clinical studies are for you.
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The National Institutes of Health (NIH) Clinical Center Search the Studies site is a registry of publicly supported clinical studies conducted mostly in Bethesda, MD.
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ResearchMatch is a nonprofit program funded by the National Institutes of Health (NIH). It helps to connect people interested in research studies with researchers from top medical centers across the U.S.
Get connected to research on many different health conditions - through ResearchMatch.
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A research study involving human volunteers (also called participants) that is intended to add to medical knowledge. There are two types of clinical studies:
A research study involving human volunteers (also called participants) that is intended to add to medical knowledge. There are two types of clinical studies:
Studies that pay near you. Browse paid clinical trial opportunities at one of our three U.S. locations in Dallas, Texas; Madison, Wisconsin; or Daytona
Find opportunities to participate in clinical research by discovering paid clinical trials near you at ICON in Lenexa, Kansas. ... Our Lenexa, KS studies.
Improvements to care are possible because of the people who volunteer to participate in clinical research. Research studies called clinical trials test how new
Below are actively recruiting clinical trials for Missouri. Click on the closest city to find the research studies that are available in your area.
The National Institutes of Health (NIH) describe clinical trials as “research studies that explore whether a medical strategy, treatment, or device is safe and
The NIH maintains an online database of clinical research studies taking place at its Clinical Center, which is located on the NIH campus in Bethesda
The National Institutes of Health (NIH) Clinical Center Search the Studies site is a registry of publicly supported clinical studies conducted mostly in
ResearchMatch helps you find a clinical trial or research study near you, or across the country, by matching you with researchers from leading medical